KYIV, Ukraine — Two Russian ballistic missiles struck an educational facility and nearby hospital in a central-eastern region of Ukraine, killing at least 41 people and wounding 180 others, Ukrainian President Volodymyr Zelenskyy said Tuesday.

The strike occurred in the city of Poltava, the capital of the region of the same name, officials said. Poltava is located about 110 kilometers (70 miles) from the border with Russia and about 350 kilometers (200 miles) southeast of Kyiv.

The strike appeared to be one of the deadliest carried out by Russian forces since the war began more than 900 days ago on Feb. 24, 2022.

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“One of the buildings of the Institute of Communications was partially destroyed. People found themselves under the rubble. Many were saved,” Zelenskyy said in a video posted on his Telegram channel.

“All necessary services are involved in the rescue operation,” he added. He said he had ordered “a full and prompt investigation” into what happened. Zelenskyy didn’t provide any further details.

The missiles hit shortly after the air raid alert sounded, when many people were on their way to a bomb shelter, Ukraine’s Defense Ministry said, describing the strike as “barbaric.”

Rescue crews and medics saved 25 people, 11 of them dug out from the rubble, a Defense Ministry statement said.

Zelenskyy repeated his appeal for Ukraine’s Western partners to ensure swift delivery of military aid. He has previously chided the U.S. and European countries for being slow to make good on their pledges of help.

He also wants them to ease restrictions on what Ukraine can target on Russian soil with the weapons they provide. Some countries fear that hitting Russia could escalate the war.

“Ukraine needs air defense systems and missiles now, not sitting in storage,” Zelenskyy wrote in English on Telegram.

“Long-range strikes that can protect us from Russian terror are needed now, not later. Every day of delay, unfortunately, means more lost lives,” he said.