An Arizona State University professor allegedly shot and killed his wife at their home while their two teenage kids were inside, according to police.

David Zhu, a professor at ASU’s W. P. Carey School of Business Department of Management and Entrepreneurship, is accused of blasting his wife, Susan Yijuan Yan, with a shotgun at their Scottsdale residence around 6:30 p.m. on Saturday night, according to the Scottsdale Police Department.

Yan, 46, was found with a gunshot wound and was taken to a local hospital where she was pronounced dead, cops said.

“This was an isolated incident that occurred inside the residence. No one else was injured from the shooting,” police said.

Zhu told police he “was trying to shoot the wall behind,” his wife, according to court documents obtained by Fox 10 Phoenix.

The professor’s children — a 19-year-old daughter and 14-year-old son — told police their parents had been involved in “frequent” domestic violence incidents, and the shooting came at the end of a fierce shouting match.

“Neither child expressed any surprise that David had shot and killed their mother,” police wrote in the court documents.

Zhu was arrested and charged with first degree murder. He was booked into Maricopa County Jail on a $1 million cash bond, according to Fox 10 Phoenix.

He had taught at ASU since 2009. The University said he is still employed as of Monday, however he has been placed on administrative leave.

He is prohibited from going on campus and from all school activities “while the university proceeds with the personnel process, according to applicable Arizona Board of Regents and local policies,” an ASU spokesperson told The Post.

“Our condolences go out to all those affected by this tragedy,” the spokesperson said in the statement.