A prosecutor says five people have been charged in connection with Matthew Perry's death from a ketamine overdose last year, including the actor's assistant and two doctors.

U.S. Attorney Martin Estrada announced the charges Thursday, saying the doctors supplied Perry with a large amount of ketamine and even wondered in a text message how much the former "Friends" star would be willing to pay.

"These defendants took advantage of Mr. Perry's addiction issues to enrich themselves. They knew what they were doing was wrong," Estrada said.

Perry died in October due to a ketamine overdose and received several injections of the drug on the day he died from his live-in personal assistant. The assistant, Kenneth Iwamasa, is the one who found Perry dead later that day.

The actor went to the two charged doctors in desperation after his regular doctors refused to give him ketamine in the amounts he wanted. DEA Administrator Anne Milgram said in one instance the actor paid $2,000 for a vial of ketamine that cost one of the physicians about $12.

Two of the people, including one of the doctors charged, were arrested Thursday, Estrada said. Two of the defendants, including Iwamasa, have pleaded guilty to charges already, and a third person has agreed to plead guilty.

Multiple messages left seeking comment from lawyers or offices for all the defendants have not yet been returned.

Among those arrested Thursday are Dr. Salvador Plasencia, who is charged with seven counts of distribution of ketamine and also two charges related to allegations he falsified records after Perry's death.
The other person arrested Thursday is Jasveen Sangha, who prosecutors described as a drug dealer known as the "ketamine queen."

Ketamine supplied by Sangha caused Perry's death, authorities said.
Sangha and Plasencia could make their first court appearances later Thursday.

Records show Plascencia's medical license has been in good standing with no records of complaints, though it is set to expire in October.

A San Diego physician, Dr. Mark Chavez, has agreed to plead guilty to conspiracy to distribute ketamine. Prosecutors allege Chavez funneled ketamine to Plasencia, securing some of the drug from a wholesale distributor through a fraudulent prescription.

The prosecutor said the defendants exchanged messages soon after Perry's death referencing ketamine as the cause of death. Estrada said they tried to cover up their involvement in supplying Perry ketamine, a powerful anesthetic that is sometimes used to treat chronic pain and depression.

Los Angeles police said in May that they were working with the U.S. Drug Enforcement Administration and the U.S. Postal Inspection Service with a probe into why the 54-year-old had so much of the surgical anesthetic in his system.

Iwamasa found the actor face down in his hot tub on Oct. 28, and paramedics who were called immediately declared him dead.

The assistant received the ketamine from Eric Fleming, who has pleaded guilty to obtaining the drug from Sangha and delivering it to Iwamasa. In all, he delivered 50 vials of ketamine for Perry's use, including 25 handed over four days before the actor's death.

Perry's autopsy, released in December, found that the amount of ketamine in his blood was in the range used for general anesthesia during surgery.

Ketamine has seen a huge surge in use in recent years as a treatment for depression, anxiety and pain. People close to Perry told coroner's investigators that he was undergoing ketamine infusion therapy.

But the medical examiner said Perry's last treatment 1½ weeks earlier wouldn't explain the levels of ketamine in his blood. The drug is typically metabolized in a matter of hours. At least two doctors were treating Perry, a psychiatrist and an anesthesiologist who served as his primary care physician, the medical examiner's report said. No illicit drugs or paraphernalia were found at his house.

Ketamine was listed as the primary cause of death, which was ruled an accident with no foul play suspected, the report said. Drowning and other medical issues were contributing factors, the coroner said.
Drug-related celebrity deaths have in other cases led authorities to prosecute the people who supplied them.

After rapper Mac Miller died from an overdose of cocaine, alcohol and counterfeit oxycodone that contained fentanyl, two of the men who provided him the fentanyl were convicted of distributing the drug. One was sentenced to more than 17 years in federal prison, the other to 10 years.

And after Michael Jackson died in 2009 from a lethal dose of propofol, a drug intended for use only during surgery and other medical procedures and not for the insomnia the singer sought it for, his doctor, Conrad Murray, was convicted of involuntary manslaughter in 2011. Murray has maintained his innocence.