JERUSALEM — Witnesses on Monday reported the first Israeli airstrike in central Beirut in nearly a year of conflict, hours after Israel struck targets across Lebanon and killed dozens of people as Hezbollah sustained a string of deadly blows to its command structure, including the killing of its overall leader, Hassan Nasrallah.

The airstrike hit a multi-story residential building, according to an Associated Press journalist at the scene. Videos showed ambulances and a crowd gathered under the building, where the strike appeared to have targeted an apartment.

In the past week, Israel has frequently targeted Beirut’s southern suburbs, where the Lebanese militant group Hezbollah has a strong presence - including a major strike on Friday that killed Hezbollah leader Hassan Nasrallah - but had not hit locations near the city center. The area where the strike took place is a primary Sunni district with a busy thoroughfare lined with shops and residentials buildings.

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There was no immediate comment from Israeli officials.

Earlier, Hezbollah confirmed that Nabil Kaouk, the deputy head of the militant group’s Central Council, was killed Saturday, making him the seventh senior Hezbollah leader slain in Israeli strikes in a little over a week. They include founding members who had evaded death or detention for decades.

Hezbollah also confirmed that Ali Karaki, another senior commander, died in a airstrike Friday strike that killed Nasrallah. Israel says at least 20 other Hezbollah militants were killed, including one in charge of Nasrallah’s security detail.

Earlier, the Lebanese health ministry documented at least 105 killed around the country in airstrikes Sunday. Two strikes near the southern city of Sidon, about 45 kilometers (28 miles) south of Beirut, killed at least 32 people, the Lebanese health ministry said. Separately, Israeli strikes in the northern province of Baalbek Hermel killed 21 people and injured at least 47. There were other strikes.

The Israeli military previously said it also carried out another targeted strike on Beirut, but did not immediately provide details.

Lebanese media reported dozens of strikes in the central, eastern and western Bekaa and in the south, besides strikes on Beirut. The strikes have targeted buildings where civilians were living and the death toll was expected to rise.

In a video of a strike in Sidon, verified by The Associated Press, a building swayed before collapsing as neighbors filmed. One TV station called on viewers to pray for a family caught under the rubble, posting their pictures, as rescuers failed to reach them. The Lebanese health ministry reported at least 14 medics were killed over two days in the south.

President Joe Biden said Sunday he would speak soon with Israeli Prime Minister Benjamin Netanyahu, and believes that an all-out war in the Middle East must be avoided.

“It has to be,” Biden told reporters at Dover Air Force Base in Delaware as he boarded Air Force One for Washington, though he didn’t say when he would call the Israeli leader.

Meanwhile, wreckage from the strike on Friday that killed Nasrallah was still smoldering. AP journalists saw smoke over the rubble as people flocked to the site, some to check on what was left of their homes and others to pay respects, pray or simply to see the destruction.

In response to the dramatic escalation in Israeli strikes on Lebanon, Hezbollah significantly increased its attacks in the past week, from several dozen to several hundred daily, the Israeli military said. The attacks injured several people and caused damage, but most of the rockets and drones were intercepted by Israel’s air defense systems or fell in open areas.

The army says its strikes have degraded Hezbollah’s capabilities and the number of launches would be much higher if Hezbollah had not been hit.

Also on Sunday, the Israeli military said dozens of its aircraft struck Houthi targets in Yemen in response to a recent attack on Israel. The military said it targeted power plants and sea port facilities in the city of Hodeida.

The Houthis launched a ballistic missile attack on Ben Gurion airport on Saturday when Netanyahu was arriving. The Houthi media office said the Israeli strikes hit the Hodeida and Rass Issa ports, along with two power plants in Hodeida city, a stronghold for the Iranian-backed rebels. The Houthi-run Health Ministry said the strikes killed four people and wounded 40 others.

The Houthis claimed they took precautionary measures ahead of the strikes, emptying oil storages in the ports, according to Nasruddin Ammer, deputy director of the Houthi media office. He said in a post on X that the strikes won’t stop the rebels’ attacks on shipping routes and on Israel.

Meanwhile, White House national security spokesman John Kirby said Israel’s airstrikes in Lebanon had “wiped out” Hezbollah’s command structure, but he warned the group will work quickly to rebuild it.

“I think people are safer without him walking around,” Kirby said of Nasrallah. “But they will try to recover. We’re watching to see what they do to try to fill this leadership vacuum. It’s going to be tough. … Much of their command structure has now been wiped out.”

Speaking on CNN’s “State of the Union,” Kirby sidestepped questions about whether the Biden administration agrees with how the Israelis are targeting Hezbollah leaders. The White House continues to call on Israel and Hezbollah to agree to a 21-day temporary cease-fire floated by the U.S., France and other countries as world leaders gathered for the U.N. General Assembly last week.

Netanyahu on Sunday appointed a former rival, Gideon Saar, to his Cabinet. The move expands Netanyahu’s governing coalition and helps entrench the Israeli leader in office.

Under their agreement, Netanyahu said Saar would be given a spot in the Security Cabinet, the body that oversees management of the ongoing war.

Saar had hoped to replace Defense Minister Yoav Gallant, another rival of Netanyahu’s. But a deal to become defense minister fell through after fighting intensified with Hezbollah.

Earlier this month, Hezbollah was also targeted by a sophisticated attack on its pagers and walkie-talkies that was widely blamed on Israel. A wave of Israeli airstrikes across large parts of Lebanon have killed more than 1,030 people - including 156 women and 87 children - in less than two weeks, according to Lebanon’s Health Ministry.

Hundreds of thousands of people have been driven from their homes in Lebanon by the latest strikes. The government estimates around 250,000 are in shelters, with three to four times as many staying with friends or relatives, or camping out on the streets.

Hezbollah, a Lebanese militant group and political party backed by Iran, Israel’s chief regional rival, rose to regional prominence after fighting a devastating monthlong war with Israel in 2006 that ended in a draw.

Kaouk was a veteran member of Hezbollah going back to the 1980s and served as Hezbollah’s military commander in southern Lebanon during the 2006 war with Israel. The United States announced sanctions against him in 2020.

Hezbollah began firing rockets, missiles and drones into northern Israel after Hamas’ Oct. 7 attack out of Gaza triggered the war there. Hezbollah and Hamas are allies that consider themselves part of an Iran-backed “Axis of Resistance” against Israel.

The conflict has steadily ratcheted up to the brink of all-out war, raising fears of a region-wide conflagration.

Israel says it is determined to return some 60,000 of its citizens to communities in the north that were evacuated nearly a year ago. Hezbollah has said it will only halt its rocket fire if there is a cease-fire in Gaza, which has proven elusive despite months of indirect negotiations between Israel and Hamas led by the United States, Qatar and Egypt.