New York hedge fund titan Boaz Weinstein, who made a fortune with a big bet against JPMorgan, is splitting from his wife, one-time Manhattan District Attorney candidate Tali Farhadian, The Post has learned.

A lawyer for Weinstein, a 51-year-old longtime Democrat donor, filed for divorce on April 4 from his wife of 14 years, who worked for Eric Holder during his spell as attorney general in the Obama administration.

Farhadian ran a big-bucks campaign with the help of her Wall Street connections against Alvin Bragg in the summer of 2021.

She also clerked for Supreme Court Justice Sandra Day O’Connor, and has served as a prosecutor at both the federal and local level.

The New York power couple got married at the Central Synagogue in Manhattan in November 2010 in a lavish ceremony led by Rabbi James Ponet, who performed the ceremony.

Filings on the New York Supreme Court docket show the terms of the divorce are contested.

“If this had been a done deal, there would have been a settlement agreement. Clearly, there is a fly in the ointment,” said top New York family lawyer Chaim Steinberger, who is not representing either party.

“The defendant felt the need to seek immediate judicial intervention,” he added, referring to a May 31 motion by her divorce attorney Ryan Casson.

Dozens of exhibits have also been filed to the court on Farhadian’s behalf by Casson. All of the filings have been sealed under court order, Steinberger said.

“Tali Farhadian Weinstein and Boaz Weinstein have decided to end their marriage. Tali is not planning to make any other public statements and hopes that her family’s privacy will be respected,” Casson told The Post in an emailed statement.

“This is an amicable dissolution involving two people who fully respect one another. They expect the divorce to be resolved quickly and hope their family’s privacy will be respected,” added a spokeswoman for Boaz Weinstein.

Property records show that the couple lived in a swanky Fifth Avenue condo on the Upper East Side near Central Park.

Weinstein paid $25.5 million in 2012 for the plush pad that once belonged to late eccentric copper heiress Huguette Clark.

The founder of Saba Capital Management recently clashed with BlackRock CEO Larry Fink over his bid to take control of a series of their closed-end funds, which pools money from investors to buy securities.

Weinstein gained prominence in 2011 following his bet against JPMorgan, reportedly netting him $300 million. He was the first to shine a light on the huge credit-default swap index trade of former JPMorgan trader Bruno Iksil, aka the London Whale.

It helped assets at his firm — housed in New York’s famed art-deco Chrysler Building — peak in 2012 at $6 billion.

Weinstein set up the company in 2009 after quitting as Deutsche Bank’s co-head of global trading.

Farhadian, whose primary race for Manhattan DA was endorsed by The Post and former Secretary of State Hillary Clinton, narrowly lost out on the Democrat nomination when she ran against the progressive Bragg in 2021.

Bragg won 34.3% of the vote to 30.7% for Farhadian, an Iranian Jew who fled to the United States at age 4 in 1979.

A Rhodes scholar at Britain’s prestigious Oxford University, she drummed up more than $2 million in donations from top New York financiers to bankroll her campaign.

They included Trump supporting money men such as Bill Ackman of Pershing Square and Citadel’s Ken Griffin.